G Protein-Coupled Receptors in Drug Discovery
Lundstrom, Kenneth H. / Chiu, Mark L.
With more than half of drug targets based on GPCRs, translating into billions in worldwide sales, there is great interest in finding high-resolution structures for recombinantly expressed GPCRs, discovering novel drug interactions, and designing tailor-made, structure-based drug therapies that display improved efficacy and selectivity with lesser side effects. This book describes the physiological role of GPCRs and their involvement in various...